Chelation-Assisted Substrate-Controlled Asymmetric Lithiation-Allylboration of Chiral Carbamate 1,2,4-Butanetriol Acetonide

Chelation-Assisted Substrate-Controlled Asymmetric Lithiation-Allylboration of Chiral Carbamate 1,2,4-Butanetriol Acetonide

The lithiation of 2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethyl diisopropylcarbamate (1) is achieved freely by sec-butyllithium in diethylether with high lk-diastereoselectivity: the bicyclic chelate complexes 3a and 3b are reacted with electrophiles to form optically active precursors 4a and 4b with &am...

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Bibliographic Details
Main Authors: Adeem Mahmood, Hamad Z. Alkhathlan, Saima Parvez, Merajuddin Khan, Sohail A. Shahzad
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Molecules
Subjects:
lithiation
borylation
allylation
chelation
Online Access:http://www.mdpi.com/1420-3049/20/6/9890

Internet

http://www.mdpi.com/1420-3049/20/6/9890

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