Insertion of an endogenous Jaagsiekte sheep retrovirus element into the BCO2 - gene abolishes its function and leads to yellow discoloration of adipose tissue in Norwegian Spælsau (Ovis aries)

Insertion of an endogenous Jaagsiekte sheep retrovirus element into the BCO2 - gene abolishes its function and leads to yellow discoloration of adipose tissue in Norwegian Spælsau (Ovis aries)

Abstract Background The accumulation of carotenoids in adipose tissue leading to yellow fat is, in sheep, a heritable recessive trait that can be attributed to a nonsense mutation in the beta-carotene oxygenase 2 (BCO2) gene. However, not all sheep breeds suffering from yellow fat have this nonsense...

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Bibliographic Details
Main Authors: Matthew Kent, Michel Moser, Inger Anne Boman, Kristine Lindtveit, Mariann Árnyasi, Kristil Kindem Sundsaasen, Dag Inge Våge
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Genomics
Subjects:
Sheep
spælsau
BCO2
Structural variant
Nanopore sequencing
Functional mutation
Online Access:https://doi.org/10.1186/s12864-021-07826-5

Internet

https://doi.org/10.1186/s12864-021-07826-5

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