Genomic Modifiers of Natural Killer Cells, Immune Responsiveness and Lymphoid Tissue Remodeling Together Increase Host Resistance to Viral Infection.

Genomic Modifiers of Natural Killer Cells, Immune Responsiveness and Lymphoid Tissue Remodeling Together Increase Host Resistance to Viral Infection.

The MHC class I D(k) molecule supplies vital host resistance during murine cytomegalovirus (MCMV) infection. Natural killer (NK) cells expressing the Ly49G2 inhibitory receptor, which specifically binds D(k), are required to control viral spread. The extent of D(k)-dependent host resistance, however...

Full description

Bibliographic Details
Main Authors: Alyssa Lundgren Gillespie, Jeffrey Teoh, Heather Lee, Jessica Prince, Michael D Stadnisky, Monique Anderson, William Nash, Claudia Rival, Hairong Wei, Awndre Gamache, Charles R Farber, Kenneth Tung, Michael G Brown
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005419

Internet

https://doi.org/10.1371/journal.ppat.1005419

Similar Items