Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons

Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset fatal motor neuron disease. In spinal motor neurons of patients with sporadic ALS, normal RNA editing of GluA2, a subunit of the L-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, is inefficient. Adenosine deamin...

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Bibliographic Details
Main Authors: Takuto Hideyama, Takenari Yamashita, Hitoshi Aizawa, Shoji Tsuji, Akiyoshi Kakita, Hitoshi Takahashi, Shin Kwak
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Neurobiology of Disease
Subjects:
RNA editing
ADAR2 (adenosine deaminase acting on RNA 2)
ALS (amyotrophic lateral sclerosis)
GluA2
AMPA
Neuronal death
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111004086

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http://www.sciencedirect.com/science/article/pii/S0969996111004086

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