Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies

Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies

Abstract Synucleinopathies, including Parkinson’s disease (PD), Lewy body dementia (LBD), Alzheimer’s disease with amygdala restricted Lewy bodies (AD/ALB), and multiple system atrophy (MSA) comprise a spectrum of neurodegenerative disorders characterized by the presence of distinct pathological α-s...

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Bibliographic Details
Main Authors: Ethan W. Hass, Zachary A. Sorrentino, Yuxing Xia, Grace M. Lloyd, John Q. Trojanowski, Stefan Prokop, Benoit I. Giasson
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Acta Neuropathologica Communications
Subjects:
Carboxy
Inclusions
Lewy body dementia
Multiple system atrophy
α-synuclein
Truncation
Online Access:https://doi.org/10.1186/s40478-021-01242-2

Internet

https://doi.org/10.1186/s40478-021-01242-2

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