How rare and common risk variation jointly affect liability for autism spectrum disorder

How rare and common risk variation jointly affect liability for autism spectrum disorder

Abstract Background Genetic studies have implicated rare and common variations in liability for autism spectrum disorder (ASD). Of the discovered risk variants, those rare in the population invariably have large impact on liability, while common variants have small effects. Yet, collectively, common...

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Bibliographic Details
Main Authors: Lambertus Klei, Lora Lee McClain, Behrang Mahjani, Klea Panayidou, Silvia De Rubeis, Anna-Carin Säll Grahnat, Gun Karlsson, Yangyi Lu, Nadine Melhem, Xinyi Xu, Abraham Reichenberg, Sven Sandin, Christina M. Hultman, Joseph D. Buxbaum, Kathryn Roeder, Bernie Devlin
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Molecular Autism
Subjects:
Genomic-Best Linear Unbiased Prediction (G-BLUP)
De novo mutation
Liability
Polygenic risk score
Autism spectrum disorder
Online Access:https://doi.org/10.1186/s13229-021-00466-2

Internet

https://doi.org/10.1186/s13229-021-00466-2

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