Prognostic Significance of NOTCH1 and FBXW7 Mutations in Pediatric T-ALL

Prognostic Significance of NOTCH1 and FBXW7 Mutations in Pediatric T-ALL

The NOTCH signaling pathway plays important role in the development of multicellular organisms, as it regulates cell proliferation, survival, and differentiation. In adults, it is essential for the T- or B-lymphocyte lineage commitment. NOTCH1 and FBXW7 mutations both lead the activation of the NOTC...

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Bibliographic Details
Main Authors: Yucel Erbilgin, Muge Sayitoglu, Ozden Hatirnaz, Omer Dogru, Arzu Akcay, Gulen Tuysuz, Tiraje Celkan, Gonul Aydogan, Zafer Salcioglu, Cetin Timur, Lebriz Yuksel-Soycan, Umit Ure, Sema Anak, Leyla Agaoglu, Omer Devecioglu, Inci Yildiz, Ugur Ozbek
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.3233/DMA-2010-0715

Internet

http://dx.doi.org/10.3233/DMA-2010-0715

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