2-[2-Methyl-5-phenyl-1-(3,4,5-trimethoxyphenyl)-1H-pyrrol-3-yl]-2-oxo-N-(pyridin-4-yl) acetamide

2-[2-Methyl-5-phenyl-1-(3,4,5-trimethoxyphenyl)-1H-pyrrol-3-yl]-2-oxo-N-(pyridin-4-yl) acetamide

We synthesized 2-[2-methyl-5-phenyl-1-(3,4,5-trimethoxyphenyl)-1H-pyrrol-3-yl]-2-oxo-N-(pyridin-4-yl) acetamide 4 as a novel compound derived from the indibulin and combretastatin scaffolds, which are known anti-mitotic agents, using a multistep reaction. We tested its cytotoxic activity against thr...

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Bibliographic Details
Main Authors: Ebrahim Saeedian Moghadam, Mohsen Amini
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molbank
Subjects:
multistep synthesis
stetter reaction
Paal-Knorr pyrrole synthesis
drug design
anti-cancer activity
MTT
Online Access:http://www.mdpi.com/1422-8599/2018/3/1002

Internet

http://www.mdpi.com/1422-8599/2018/3/1002

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