NAC and Vitamin D Restore CNS Glutathione in Endotoxin-Sensitized Neonatal Hypoxic-Ischemic Rats

NAC and Vitamin D Restore CNS Glutathione in Endotoxin-Sensitized Neonatal Hypoxic-Ischemic Rats

Therapeutic hypothermia does not improve outcomes in neonatal hypoxia ischemia (HI) complicated by perinatal infection, due to well-described, pre-existing oxidative stress and neuroinflammation that shorten the therapeutic window. For effective neuroprotection post-injury, we must first define and...

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Bibliographic Details
Main Authors: Lauren E. Adams, Hunter G. Moss, Danielle W. Lowe, Truman Brown, Donald B. Wiest, Bruce W. Hollis, Inderjit Singh, Dorothea D. Jenkins
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antioxidants
Subjects:
glutathione
glutamate
oxidative stress
hypoxia ischemia
endotoxin
magnetic resonance spectroscopy
Online Access:https://www.mdpi.com/2076-3921/10/3/489

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https://www.mdpi.com/2076-3921/10/3/489

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