Anti-gp120 minibody gene transfer to female genital epithelial cells protects against HIV-1 virus challenge in vitro.

Anti-gp120 minibody gene transfer to female genital epithelial cells protects against HIV-1 virus challenge in vitro.

Although cervico-vaginal epithelial cells of the female lower genital tract provide the initial defense system against HIV-1 infection, the protection is sometimes incomplete. Thus, enhancing anti-HIV-1 humoral immunity at the mucosal cell surface by local expression of anti-HIV-1 broadly neutralizi...

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Bibliographic Details
Main Authors: Ussama M Abdel-Motal, Phuong T N Sarkis, Thomas Han, Jeffery Pudney, Deborah J Anderson, Quan Zhu, Wayne A Marasco
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3198777?pdf=render

Internet

http://europepmc.org/articles/PMC3198777?pdf=render

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