Kinin B1 receptor antagonism is equally efficient as angiotensin receptor 1 antagonism in reducing renal fibrosis in experimental obstructive nephropathy, but is not additive.

Kinin B1 receptor antagonism is equally efficient as angiotensin receptor 1 antagonism in reducing renal fibrosis in experimental obstructive nephropathy, but is not additive.

Background: Renal tubulointerstitial fibrosis is the pathological hallmark of chronic kidney disease. Currently, inhibitors of the renin angiotensin system (RAS) remain the sole therapy in human displaying antifibrotic properties. Further antifibrotic molecules are needed. We have recently reported...

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Bibliographic Details
Main Authors: Antoine eHuart, Julie eKlein, Julien eGonzalez, Bénedicte eBuffin-Meyer, Eric eNeau, Christine eDelage, Denis eCalise, David eRibes, Joost-Peter eSchanstra, Jean-Loup eBascands
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Pharmacology
Subjects:
combined therapy
Bradykinin B1 receptor
Angiotensin receptor inhibition
low density array
renal fibrosis.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00008/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00008/full

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