An alternative trial-level measure for evaluating failure-time surrogate endpoints based on prediction error

To validate a failure-time surrogate for an established failure-time clinical endpoint such as overall survival, the meta-analytic approach is commonly used. The standard correlation approach considers two levels: the individual level, with Kendall's τ measuring the rank correlation between the...

Full description

Bibliographic Details
Main Authors: Shaima Belhechmi, Stefan Michiels, Xavier Paoletti, Federico Rotolo
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Contemporary Clinical Trials Communications
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865419300183