Involvement of the Na+/Ca2+ Exchanger in Ouabain-Induced Inotropy and Arrhythmogenesis in Guinea-Pig Myocardium as Revealed by SEA0400

Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis was examined with a specific inhibitor, SEA0400. In right ventricular papillary muscle isolated from guinea-pig ventricle, 1 µM SEA0400, which specifically inhibits the Na+/Ca2+ exchanger by 80%, reduced the ouaba...

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Bibliographic Details
Main Authors: Hikaru Tanaka, Hideaki Shimada, Iyuki Namekata, Toru Kawanishi, Naoko Iida-Tanaka, Koki Shigenobu
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319343300