Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)

The effects of quinacrine and minocycline on the toxicity induced by hPrP90-231 were studied. By mild thermal denaturation, hPrP90-231 can be converted in a toxic PrP<sup>Sc</sup>-like structure affecting the survival of SH-SY5Y cells. Quinacrine and minocycline prevented hPrP90-231-indu...

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Main Authors:	V. Villa, A. Corsaro, S. Thellung, A. Simi, M. Nizzari, M. Tonelli, V. Boido, A. Aceto, T. Florio
Format:	Article
Language:	English
Published:	PAGEPress Publications 2011-01-01
Series:	Journal of Biological Research
Subjects:	prion protein, quinacrine, minocycline
Online Access:	http://www.pagepressjournals.org/index.php/jbr/article/view/4689

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spelling	doaj-4de89126e8bb4db48737ffbd6150bb992020-11-25T03:53:40ZengPAGEPress PublicationsJournal of Biological Research1826-88382284-02302011-01-0184110.4081/jbr.2011.46893836Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)V. VillaA. CorsaroS. ThellungA. SimiM. NizzariM. TonelliV. BoidoA. AcetoT. FlorioThe effects of quinacrine and minocycline on the toxicity induced by hPrP90-231 were studied. By mild thermal denaturation, hPrP90-231 can be converted in a toxic PrP<sup>Sc</sup>-like structure affecting the survival of SH-SY5Y cells. Quinacrine and minocycline prevented hPrP90-231-induced toxicity interfering with different mechanisms: protective effects of quinacrine are mediated by the binding to the fragment that abolished hPrP90-231 structural changes and cell internalization, whereas, minocycline reverted MAP kinase neurotoxic signaling exerted by the prion fragment.http://www.pagepressjournals.org/index.php/jbr/article/view/4689prion protein, quinacrine, minocycline
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	V. Villa A. Corsaro S. Thellung A. Simi M. Nizzari M. Tonelli V. Boido A. Aceto T. Florio
spellingShingle	V. Villa A. Corsaro S. Thellung A. Simi M. Nizzari M. Tonelli V. Boido A. Aceto T. Florio Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231) Journal of Biological Research prion protein, quinacrine, minocycline
author_facet	V. Villa A. Corsaro S. Thellung A. Simi M. Nizzari M. Tonelli V. Boido A. Aceto T. Florio
author_sort	V. Villa
title	Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)
title_short	Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)
title_full	Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)
title_fullStr	Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)
title_full_unstemmed	Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)
title_sort	molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hprp90-231)
publisher	PAGEPress Publications
series	Journal of Biological Research
issn	1826-8838 2284-0230
publishDate	2011-01-01
description	The effects of quinacrine and minocycline on the toxicity induced by hPrP90-231 were studied. By mild thermal denaturation, hPrP90-231 can be converted in a toxic PrP<sup>Sc</sup>-like structure affecting the survival of SH-SY5Y cells. Quinacrine and minocycline prevented hPrP90-231-induced toxicity interfering with different mechanisms: protective effects of quinacrine are mediated by the binding to the fragment that abolished hPrP90-231 structural changes and cell internalization, whereas, minocycline reverted MAP kinase neurotoxic signaling exerted by the prion fragment.
topic	prion protein, quinacrine, minocycline
url	http://www.pagepressjournals.org/index.php/jbr/article/view/4689
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Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)

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