Molecular mechanisms mediating the neuroproyective effects of quinacrine and minocycline on cell death induced by the prion protein fragment 90-231 (hPrP90-231)
The effects of quinacrine and minocycline on the toxicity induced by hPrP90-231 were studied. By mild thermal denaturation, hPrP90-231 can be converted in a toxic PrP<sup>Sc</sup>-like structure affecting the survival of SH-SY5Y cells. Quinacrine and minocycline prevented hPrP90-231-indu...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2011-01-01
|
| Series: | Journal of Biological Research |
| Subjects: | |
| Online Access: | http://www.pagepressjournals.org/index.php/jbr/article/view/4689 |