Modulated electro‐hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro

Modulated electro‐hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro

Abstract Objective Modulated electro‐hyperthermia (mEHT), a noninvasive complementary treatment of human chemo‐ and radiotherapy, can generate selective ~42°C heat in cancer due to elevated glycolysis (Warburg‐effect) and electric conductivity in malignant tissues. Here we tested the molecular backg...

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Bibliographic Details
Main Authors: Tamas Vancsik, Gertrud Forika, Andrea Balogh, Eva Kiss, Tibor Krenacs
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Cancer Medicine
Subjects:
caspase dependent apoptosis
colorectal cancer
doxorubicin potentiation
modulated electro‐hyperthermia
p53 and p21waf1 upregulation
tumor senescence
Online Access:https://doi.org/10.1002/cam4.2330

Internet

https://doi.org/10.1002/cam4.2330

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