Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria.

Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria.

Mutations in Pten-induced kinase 1 (PINK1) are linked to early-onset familial Parkinson's disease (FPD). PINK1 has previously been implicated in mitochondrial fission/fusion dynamics, quality control, and electron transport chain function. However, it is not clear how these processes are interc...

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Bibliographic Details
Main Authors: Song Liu, Tomoyo Sawada, Seongsoo Lee, Wendou Yu, George Silverio, Philomena Alapatt, Ivan Millan, Alice Shen, William Saxton, Tomoko Kanao, Ryosuke Takahashi, Nobutaka Hattori, Yuzuru Imai, Bingwei Lu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3291531?pdf=render

Internet

http://europepmc.org/articles/PMC3291531?pdf=render

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