Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice

Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice

Abstract Background Treatment with the α-glucosidase inhibitor acarbose increases median lifespan by approximately 20% in male mice and 5% in females. This longevity extension differs from dietary restriction based on a number of features, including the relatively small effects on weight and the sex...

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Bibliographic Details
Main Authors: Byron J Smith, Richard A Miller, Aaron C Ericsson, David C Harrison, Randy Strong, Thomas M Schmidt
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Microbiology
Subjects:
Acarbose
Longevity
Gut microbiome
Short-chain fatty acids
Muribaculaceae
S24-7
Online Access:http://link.springer.com/article/10.1186/s12866-019-1494-7

Internet

http://link.springer.com/article/10.1186/s12866-019-1494-7

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