Cleavage of the vesicular glutamate transporters under excitotoxic conditions

Cleavage of the vesicular glutamate transporters under excitotoxic conditions

Glutamate is loaded into synaptic vesicles by vesicular glutamate transporters (VGLUTs), and alterations in the transporters expression directly regulate neurotransmitter release. We investigated changes in VGLUT1 and VGLUT2 protein levels after ischemic and excitotoxic insults. The results show tha...

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Bibliographic Details
Main Authors: Andrea C. Lobo, João R. Gomes, Tatiana Catarino, Miranda Mele, Pedro Fernandez, Ana R. Inácio, Ben A. Bahr, Armanda E. Santos, Tadeusz Wieloch, Ana Luísa Carvalho, Carlos B. Duarte
Format: Article
Language:English
Published: Elsevier 2011-12-01
Series:Neurobiology of Disease
Subjects:
Brain ischemia
Calpains
Excitotoxicity
Oxygen and glucose deprivation
Vesicular glutamate transporters
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111002361

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http://www.sciencedirect.com/science/article/pii/S0969996111002361

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