Identification of peptides interfering with the LRRK2/PP1 interaction.

Serine/threonine phosphatases are responsible for modulating the activities of the protein kinases implicated in the development of several pathologies. Here we identified by a PEP-scan approach a peptide of LRRK2, a Parkinson's disease associated protein, interacting with the phosphatase PP1....

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Bibliographic Details
Main Authors: Chang Zhi Dong, Heriberto Bruzzoni-Giovanelli, Yanhua Yu, Karim Dorgham, Christophe Parizot, Jean Marc Zini, Jean Yves Brossas, Pierre Tuffery, Angelita Rebollo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0237110