A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay.

A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay.

The nonsense-mediated decay (NMD) pathway subjects mRNAs with premature termination codons (PTCs) to rapid decay. The conserved Upf1-3 complex interacts with the eukaryotic translation release factors, eRF3 and eRF1, and triggers NMD when translation termination takes place at a PTC. Contrasting mod...

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Bibliographic Details
Main Authors: Guramrit Singh, Indrani Rebbapragada, Jens Lykke-Andersen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-04-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2689706?pdf=render

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http://europepmc.org/articles/PMC2689706?pdf=render

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