IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α

Molecular mechanisms regulating the development of inhibitory synapses are poorly understood. Here the authors show that IgSF21 interacts with neurexin2α to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission.

Bibliographic Details
Main Authors:	Yuko Tanabe, Yusuke Naito, Cristina Vasuta, Alfred Kihoon Lee, Youssouf Soumounou, Michael W. Linhoff, Hideto Takahashi
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00333-w

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spelling	doaj-4d91186d6dcd4afaac0d8d568c1932df2021-05-11T07:04:45ZengNature Publishing GroupNature Communications2041-17232017-09-018111510.1038/s41467-017-00333-wIgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2αYuko Tanabe0Yusuke Naito1Cristina Vasuta2Alfred Kihoon Lee3Youssouf Soumounou4Michael W. Linhoff5Hideto Takahashi6Synapse Development and Plasticity Research Unit, Institut de RecherchesCliniques de MontréalSynapse Development and Plasticity Research Unit, Institut de RecherchesCliniques de MontréalSynapse Development and Plasticity Research Unit, Institut de RecherchesCliniques de MontréalSynapse Development and Plasticity Research Unit, Institut de RecherchesCliniques de MontréalSynapse Development and Plasticity Research Unit, Institut de RecherchesCliniques de MontréalDepartment of Anatomy and Neurobiology, Washington University School of MedicineSynapse Development and Plasticity Research Unit, Institut de RecherchesCliniques de MontréalMolecular mechanisms regulating the development of inhibitory synapses are poorly understood. Here the authors show that IgSF21 interacts with neurexin2α to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission.https://doi.org/10.1038/s41467-017-00333-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yuko Tanabe Yusuke Naito Cristina Vasuta Alfred Kihoon Lee Youssouf Soumounou Michael W. Linhoff Hideto Takahashi
spellingShingle	Yuko Tanabe Yusuke Naito Cristina Vasuta Alfred Kihoon Lee Youssouf Soumounou Michael W. Linhoff Hideto Takahashi IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α Nature Communications
author_facet	Yuko Tanabe Yusuke Naito Cristina Vasuta Alfred Kihoon Lee Youssouf Soumounou Michael W. Linhoff Hideto Takahashi
author_sort	Yuko Tanabe
title	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
title_short	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
title_full	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
title_fullStr	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
title_full_unstemmed	IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α
title_sort	igsf21 promotes differentiation of inhibitory synapses via binding to neurexin2α
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-09-01
description	Molecular mechanisms regulating the development of inhibitory synapses are poorly understood. Here the authors show that IgSF21 interacts with neurexin2α to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission.
url	https://doi.org/10.1038/s41467-017-00333-w
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IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α

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