IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α

IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α

Molecular mechanisms regulating the development of inhibitory synapses are poorly understood. Here the authors show that IgSF21 interacts with neurexin2α to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission.

Bibliographic Details
Main Authors: Yuko Tanabe, Yusuke Naito, Cristina Vasuta, Alfred Kihoon Lee, Youssouf Soumounou, Michael W. Linhoff, Hideto Takahashi
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00333-w

Internet

https://doi.org/10.1038/s41467-017-00333-w

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