No evidence for interactions of dimethylfumarate (DMF) and its main metabolite monomethylfumarate (MMF) with human cytochrome P450 (CYP) enzymes and the P‐glycoprotein (P‐gp) drug transporter

No evidence for interactions of dimethylfumarate (DMF) and its main metabolite monomethylfumarate (MMF) with human cytochrome P450 (CYP) enzymes and the P‐glycoprotein (P‐gp) drug transporter

Abstract Dimethylfumarate (DMF) has long been used as part of a fixed combination of fumaric acid esters (FAE) in some European countries and is now available as an oral monotherapy for psoriasis. The present investigation determined whether DMF and its main metabolite monomethylfumarate (MMF) inter...

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Bibliographic Details
Main Authors: Jordi Aubets, Josep‐Maria Jansat, Miquel Salva, Vicky M. Birks, Richard J. Cole, Jenny Lewis, Annabell Pitcher, Michael Hall
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Pharmacology Research & Perspectives
Subjects:
cytochrome P450
dimethylfumarate
drug metabolism
drug‐drug interactions
fumaric acid esters
monomethylfumarate
Online Access:https://doi.org/10.1002/prp2.540

Internet

https://doi.org/10.1002/prp2.540

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