Desialylation of platelets induced by Von Willebrand Factor is a novel mechanism of platelet clearance in dengue.

Desialylation of platelets induced by Von Willebrand Factor is a novel mechanism of platelet clearance in dengue.

Thrombocytopenia and platelet dysfunction are commonly observed in patients with dengue virus (DENV) infection and may contribute to complications such as bleeding and plasma leakage. The etiology of dengue-associated thrombocytopenia is multifactorial and includes increased platelet clearance. The...

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Bibliographic Details
Main Authors: Silvita Fitri Riswari, Rahajeng N Tunjungputri, Vesla Kullaya, Fadel M Garishah, Gloria S R Utari, Nur Farhanah, Gijs J Overheul, Bachti Alisjahbana, M Hussein Gasem, Rolf T Urbanus, Philip G de Groot, Dirk J Lefeber, Ronald P van Rij, Andre van der Ven, Quirijn de Mast
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6426266?pdf=render

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http://europepmc.org/articles/PMC6426266?pdf=render

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