Recombinant monovalent llama-derived antibody fragments (VHH) to rotavirus VP6 protect neonatal gnotobiotic piglets against human rotavirus-induced diarrhea.

Recombinant monovalent llama-derived antibody fragments (VHH) to rotavirus VP6 protect neonatal gnotobiotic piglets against human rotavirus-induced diarrhea.

Group A Rotavirus (RVA) is the leading cause of severe diarrhea in children. The aims of the present study were to determine the neutralizing activity of VP6-specific llama-derived single domain nanoantibodies (VHH nanoAbs) against different RVA strains in vitro and to evaluate the ability of G6P[1]...

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Bibliographic Details
Main Authors: Celina G Vega, Marina Bok, Anastasia N Vlasova, Kuldeep S Chattha, Silvia Gómez-Sebastián, Carmen Nuñez, Carmen Alvarado, Rodrigo Lasa, José M Escribano, Lorena L Garaicoechea, Fernando Fernandez, Karin Bok, Andrés Wigdorovitz, Linda J Saif, Viviana Parreño
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3642062?pdf=render

Internet

http://europepmc.org/articles/PMC3642062?pdf=render

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