Synthetic Studies on Bioactive Natural Polyketides: Intramolecular Nitrile Oxide-Olefin Cycloaddition Approach for Construction of a Macrolactone Skeleton of Macrosphelide B

Synthetic Studies on Bioactive Natural Polyketides: Intramolecular Nitrile Oxide-Olefin Cycloaddition Approach for Construction of a Macrolactone Skeleton of Macrosphelide B

Studies on the synthesis of macrosphelide B via an intramolecular nitrile oxide-olefin cycloaddition (INOC) is described. In particular, an asymmetric INOC approach using phase transfer catalysts seems to be a potentially efficient and versatile procedure for the construction of the macrolactone ske...

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Bibliographic Details
Main Authors: Seung-Mann Paek, Young-Ger Suh
Format: Article
Language:English
Published: MDPI AG 2011-06-01
Series:Molecules
Subjects:
intramolecular nitrile oxide cycloaddition
macrosphelide
polyketide
total synthesis
phase transfer catalyst
Online Access:http://www.mdpi.com/1420-3049/16/6/4850/

Internet

http://www.mdpi.com/1420-3049/16/6/4850/

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