Case Report: Detection of Double ROS1 Translocations, SDC4-ROS1 and ROS1-GK, in a Lung Adenocarcinoma Patient and Response to Crizotinib

Case Report: Detection of Double ROS1 Translocations, SDC4-ROS1 and ROS1-GK, in a Lung Adenocarcinoma Patient and Response to Crizotinib

ROS1 rearrangement, identified in ~2% of non-small cell lung cancer (NSCLC), has defined a distinctive molecular subtype. Patients with ROS1 fusion have been shown to be highly sensitive to treatment with crizotinib. However, the efficacy of crizotinib in NSCLC patients with double ROS1 fusions rema...

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Bibliographic Details
Main Authors: Long Xu, Xiaoxia Chen, Hong Huo, Yongye Liu, Xiaodan Yang, Dejian Gu, Mingming Yuan, Min Zhang, Rongrong Chen, Jiayin Wang, Zhendong Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Medicine
Subjects:
next-generation sequencing
lung adenocarcinoma
double ROS1 fusion
crizotinib
novel ROS1 fusion
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.649177/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.649177/full

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