Systemic Inflammation Increases the Susceptibility to Levodopa-Induced Dyskinesia in 6-OHDA Lesioned Rats by Targeting the NR2B-Medicated PKC/MEK/ERK Pathway

Systemic Inflammation Increases the Susceptibility to Levodopa-Induced Dyskinesia in 6-OHDA Lesioned Rats by Targeting the NR2B-Medicated PKC/MEK/ERK Pathway

Background: The long-term administration of levodopa (L-dopa), the gold-standard treatment for Parkinson's disease (PD), is irreparably associated with L-dopa-induced dyskinesia (LID), which dramatically affects the quality of life of patients. However, the underlying molecular mechanisms of ho...

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Bibliographic Details
Main Authors: Aijuan Yan, Lu Song, Yu Zhang, Xijin Wang, Zhenguo Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
L-dopa induced dyskinesia
Parkinson's disease
systemic inflammation
NR2B
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2020.625166/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2020.625166/full

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