Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication

Synthetic Lethality between DNA Polymerase Epsilon and RTEL1 in Metazoan DNA Replication

Summary: Genome stability requires coordination of DNA replication origin activation and replication fork progression. RTEL1 is a regulator of homologous recombination (HR) implicated in meiotic cross-over control and DNA repair in C. elegans. Through a genome-wide synthetic lethal screen, we uncove...

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Bibliographic Details
Main Authors: Roberto Bellelli, Jillian Youds, Valerie Borel, Jennifer Svendsen, Visnja Pavicic-Kaltenbrunner, Simon J. Boulton
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
RTEL1
DNA polymerase epsilon
DNA replication
origin activation
genome stability
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306288

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http://www.sciencedirect.com/science/article/pii/S2211124720306288

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