Dual endothelin receptor antagonism: setting standards in PAH
Endothelin (ET) has emerged as a key mediator in the pathophysiology of pulmonary arterial hypertension (PAH). The effects of ET are mediated by its binding to two receptors on endothelial and pulmonary smooth muscle cells: ETA and ETB. Blockade of both these receptors with the oral dual ET receptor...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2007-08-01
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| Series: | European Respiratory Review |
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| Online Access: | http://err.ersjournals.com/cgi/content/full/16/102/13 |