Stable cytotoxic T cell escape mutation in hepatitis C virus is linked to maintenance of viral fitness.

Stable cytotoxic T cell escape mutation in hepatitis C virus is linked to maintenance of viral fitness.

Mechanisms by which hepatitis C virus (HCV) evades cellular immunity to establish persistence in chronically infected individuals are not clear. Mutations in human leukocyte antigen (HLA) class I-restricted epitopes targeted by CD8(+) T cells are associated with persistence, but the extent to which...

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Bibliographic Details
Main Authors: Luke Uebelhoer, Jin-Hwan Han, Benoit Callendret, Guaniri Mateu, Naglaa H Shoukry, Holly L Hanson, Charles M Rice, Christopher M Walker, Arash Grakoui
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2518852?pdf=render

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http://europepmc.org/articles/PMC2518852?pdf=render

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