Ocular-motor profile and effects of memantine in a familial form of adult cerebellar ataxia with slow saccades and square wave saccadic intrusions.

Ocular-motor profile and effects of memantine in a familial form of adult cerebellar ataxia with slow saccades and square wave saccadic intrusions.

Fixation instability due to saccadic intrusions is a feature of autosomal recessive spinocerebellar ataxias, and includes square wave intrusions (SWI) and macrosaccadic oscillations (MSO). A recent report suggested that the non-competitive antagonist of NMDA receptors, memantine, could decrease MSO...

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Bibliographic Details
Main Authors: Francesca Rosini, Pamela Federighi, Elena Pretegiani, Pietro Piu, R John Leigh, Alessandro Serra, Antonio Federico, Alessandra Rufa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3718679?pdf=render

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http://europepmc.org/articles/PMC3718679?pdf=render

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