Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects

Serum high mobility group box-1 and osteoprotegerin levels are associated with peripheral arterial disease and critical limb ischemia in type 2 diabetic subjects

Abstract Background High mobility group box-1 (HMGB-1) is a nuclear protein also acting as inflammatory mediator, whilst osteoprotegerin (OPG), member of tumor necrosis factor receptor superfamily, is indicated as marker of vascular calcification. Peripheral artery disease (PAD) and type 2 diabetes...

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Bibliographic Details
Main Authors: Silvia Giovannini, Giovanni Tinelli, Federico Biscetti, Giuseppe Straface, Flavia Angelini, Dario Pitocco, Luciana Mucci, Raffaele Landolfi, Andrea Flex
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Cardiovascular Diabetology
Subjects:
HMGB-1
OPG
PAD
Type 2 diabetes
Online Access:http://link.springer.com/article/10.1186/s12933-017-0581-z

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http://link.springer.com/article/10.1186/s12933-017-0581-z

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