In vivo and ex vivo assessment of bladder hyper-permeability and using molecular targeted magnetic resonance imaging to detect claudin-2 in a mouse model for interstitial cystitis.

In vivo and ex vivo assessment of bladder hyper-permeability and using molecular targeted magnetic resonance imaging to detect claudin-2 in a mouse model for interstitial cystitis.

<h4>Objectives</h4>To determine if the URO-MCP-1 mouse model for bladder IC/BPS is associated with in vivo bladder hyper-permeability, as measured by contrast-enhanced MRI (CE-MRI), and assess whether molecular-targeted MRI (mt-MRI) can visualize in vivo claudin-2 expression as a result...

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Bibliographic Details
Main Authors: Nataliya Smith, Debra Saunders, Megan Lerner, Michelle Zalles, Nadezda Mamedova, Daniel Cheong, Ehsan Mohammadi, Tian Yuan, Yi Luo, Robert E Hurst, Beverley Greenwood-Van Meerveld, Rheal A Towner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0239282

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https://doi.org/10.1371/journal.pone.0239282

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