Quality by design (QbD) approach to formulate in situ gelling system for nose to brain delivery of Fluoxetine hydrochloride: Ex-vivo and In-vivo study
ABSTRACT Objective: The purpose of the present study is to develop an ion sensitive in situ nasal gel of Fluoxetine hydrochloride for brain delivery. A 32 factorial design was used to investigate effect of independent variable on dependent variables. Methods: Formulations were evaluated for gelati...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Facultad de Farmacia, Universidad de Granada
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| Series: | Ars Pharmaceutica |
| Subjects: | |
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S2340-98942017000300004&lng=en&tlng=en |