A New Computer Model for Evaluating the Selective Binding Affinity of Phenylalkylamines to T-Type Ca<sup>2+</sup> Channels
To establish a computer model for evaluating the binding affinity of phenylalkylamines (PAAs) to T-type Ca<sup>2+</sup> channels (TCCs), we created new homology models for both TCCs and a L-type calcium channel (LCC). We found that PAAs have a high affinity for domains I and IV of TCCs a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-02-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/14/2/141 |