Inhibition of human carboxylesterases by ginsenosides: structure–activity relationships and inhibitory mechanism

Inhibition of human carboxylesterases by ginsenosides: structure–activity relationships and inhibitory mechanism

Abstract Background Human carboxylesterases (hCES) are key serine hydrolases responsible for the hydrolysis of a wide range of endogenous and xenobiotic esters. Although it has been reported that some ginsenosides can modulate the activities of various enzymes, the inhibitory effects of ginsenosides...

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Bibliographic Details
Main Authors: Zhao-Hui Sun, Jing Chen, Yun-Qing Song, Tong-Yi Dou, Li-Wei Zou, Da-Cheng Hao, Hai-Bin Liu, Guang-Bo Ge, Ling Yang
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Chinese Medicine
Subjects:
Ginsenosides
Human carboxylesterases (hCES)
Structure–inhibition relationships
Selectivity
Inhibitory mechanism
Online Access:https://doi.org/10.1186/s13020-019-0279-0

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