Engineering CRISPR interference system in Klebsiella pneumoniae for attenuating lactic acid synthesis

Engineering CRISPR interference system in Klebsiella pneumoniae for attenuating lactic acid synthesis

Abstract Background Klebsiella pneumoniae is a promising industrial species for bioproduction of bulk chemicals such as 1,3-propanediol, 2,3-butanediol and 3-hydroxypropionic acid (3-HP). However, lactic acid is a troublesome by-product when optimizing for 3-HP production. Therefore, it is highly de...

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Bibliographic Details
Main Authors: Jingxuan Wang, Peng Zhao, Ying Li, Lida Xu, Pingfang Tian
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Microbial Cell Factories
Subjects:
CRISPR interference
Klebsiella pneumoniae
3-Hydroxypropionic acid
Lactic acid
Lactate dehydrogenase
Online Access:http://link.springer.com/article/10.1186/s12934-018-0903-1

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http://link.springer.com/article/10.1186/s12934-018-0903-1

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