In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability.

In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability.

It has long been thought that signal joints, the byproducts of V(D)J recombination, are not involved in the dynamics of the rearrangement process. Evidence has now started to accumulate that this is not the case, and that signal joints play unsuspected roles in events that might compromise genomic i...

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Main Authors: Katrina Vanura, Bertrand Montpellier, Trang Le, Salvatore Spicuglia, Jean-Marc Navarro, Olivier Cabaud, Sandrine Roulland, Elodie Vachez, Immo Prinz, Pierre Ferrier, Rodrig Marculescu, Ulrich Jäger, Bertrand Nadel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-03-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1820826?pdf=render

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