Leveraging Public Single-Cell and Bulk Transcriptomic Datasets to Delineate MAIT Cell Roles and Phenotypic Characteristics in Human Malignancies

Leveraging Public Single-Cell and Bulk Transcriptomic Datasets to Delineate MAIT Cell Roles and Phenotypic Characteristics in Human Malignancies

Mucosa-associated invariant T (MAIT) cells are unconventional, innate-like T lymphocytes that recognize vitamin B metabolites of microbial origin among other antigens displayed by the monomorphic molecule MHC class I-related protein 1 (MR1). Abundant in human tissues, reactive to local inflammatory...

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Bibliographic Details
Main Authors: Tony Yao, Parisa Shooshtari, S. M. Mansour Haeryfar
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
MAIT cells
cancer
transcriptomics
RNA sequencing
TCGA
survival
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01691/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01691/full

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