BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus

BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus

BACE1 is validated as Alzheimer's β-secretase and a therapeutic target for Alzheimer's disease. In examining BACE1-null mice, we discovered that BACE1 deficiency develops abnormal clusters of immature neurons, forming doublecortin-positive neuroblasts, in the developing dentate gyrus, main...

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Bibliographic Details
Main Authors: Hailong Hou, Qingyuan Fan, Wanxia He, Hoonkyo Suh, Xiangyou Hu, Riqiang Yan
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Stem Cell Reports
Subjects:
BACE1
Alzheimer's secretase
neuronal cluster
doublecortin
neuronal migration
neurogenesis
subpial zone
meninges
subgranular zone
granule cell layer
reelin
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117302370

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http://www.sciencedirect.com/science/article/pii/S2213671117302370

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