Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells

Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells

In mammalian cells, levels of the integral membrane proteins 3-hydroxy-3-methylglutaryl-CoA reductase and Insig-1 are controlled by lipid-regulated endoplasmic reticulum-associated degradation (ERAD). The ERAD of reductase slows a rate-limiting step in cholesterol synthesis and results from sterol-i...

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Bibliographic Details
Main Authors: Rebecca A. Faulkner, Andrew D. Nguyen, Youngah Jo, Russell A. DeBose-Boyd
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Journal of Lipid Research
Subjects:
endoplasmic reticulum-associated degradation
lipid metabolism
ubiquitin ligase
cytosolic dislocation
3-hydroxy-3-methylglutaryl-CoA
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520422059

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http://www.sciencedirect.com/science/article/pii/S0022227520422059

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