Conditional Knockdown of Osteopontin Inhibits Breast Cancer Skeletal Metastasis

Conditional Knockdown of Osteopontin Inhibits Breast Cancer Skeletal Metastasis

High osteopontin (OPN) expression is linked to breast cancer bone metastasis. In this study we modulated osteopontin levels conditionally and investigated any related antineoplastic effects. Therefore, we established cell clones from human breast cancer MDA-MB-231 cells, in which the expression of O...

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Bibliographic Details
Main Authors: Marineta Kovacheva, Michael Zepp, Muriel Schraad, Stefan Berger, Martin R. Berger
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
conditional osteopontin knockdown
tet-off system
mda-mb-231 human breast cancer cells
skeletal metastasis
erufosine
Online Access:https://www.mdpi.com/1422-0067/20/19/4918

Internet

https://www.mdpi.com/1422-0067/20/19/4918

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