The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

PCSK9 is a secreted protein that regulates plasma cholesterol levels and cardiovascular disease risk. Prior studies suggested the presence of an ER cargo receptor that recruits PCSK9 into the secretory pathway, but its identity has remained elusive. Here, we apply a novel approach that combines prox...

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Bibliographic Details
Main Authors: Brian T Emmer, Geoffrey G Hesketh, Emilee Kotnik, Vi T Tang, Paul J Lascuna, Jie Xiang, Anne-Claude Gingras, Xiao-Wei Chen, David Ginsburg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
secretion
cholesterol
PCSK9
SURF4
cargo receptor
Online Access:https://elifesciences.org/articles/38839

Internet

https://elifesciences.org/articles/38839

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