Impact of Janus Kinase Inhibition on the Treatment of Axial Spondyloarthropathies

Impact of Janus Kinase Inhibition on the Treatment of Axial Spondyloarthropathies

Many immune cells and effector molecules (e.g. cytokines, Interferons, growth factors) utilize different combinations of Janus kinase (JAK) and signal transducer and activator of transcription (STAT) molecules to transduce signals from the cell surface to the nucleus, where they regulate transcripti...

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Bibliographic Details
Main Authors: Ariane Hammitzsch, Georg Lorenz, Philipp Moog
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
JAK – STAT signalling pathway
small molecule inhibitor
axial spondyloarthritis
preclinical efficacy and tolerability
safety profile
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.591176/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.591176/full

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