Restrictive cardiomyopathy caused by troponin mutations: Application of disease animal models in translational studies

Restrictive cardiomyopathy caused by troponin mutations: Application of disease animal models in translational studies

Cardiac troponin I (cTnI) plays a critical role in regulation of cardiac function. In pathological conditions, the deficiency of cTnI or mutations in cTnI especially in the C-terminus of cTnI is associated with diastolic dysfunction caused by myofibril hypersensitivity to Ca2+. The first clinical st...

Full description

Bibliographic Details
Main Authors: Xiaoyan Liu, Lei Zhang, Daniel Pacciulli, Jianquan Zhao, Changlong Nan, Wen Shen, Junjun Quan, Jie Tian, Xupei Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Physiology
Subjects:
Mutation
Myofibrils
Troponin
Animal Models
cardiomyopathy
diastolic dysfunction
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00629/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00629/full

Similar Items