Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors

Scaffold proteins LACK and TRACK as potential drug targets in kinetoplastid parasites: Development of inhibitors

Parasitic diseases cause ∼500,000 deaths annually and remain a major challenge for therapeutic development. Using a rational design based approach, we developed peptide inhibitors with anti-parasitic activity that were derived from the sequences of parasite scaffold proteins LACK (Leishmania's...

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Bibliographic Details
Main Authors: Nir Qvit, Deborah Schechtman, Darlene Aparecida Pena, Denise Aparecida Berti, Chrislaine Oliveira Soares, Qianqian Miao, Liying (Annie) Liang, Lauren A. Baron, Christian Teh-Poot, Pedro Martínez-Vega, Maria Jesus Ramirez-Sierra, Eric Churchill, Anna D. Cunningham, Andrey V. Malkovskiy, Nancy A. Federspiel, Fabio Cesar Gozzo, Ana Claudia Torrecilhas, Maria Julia Manso Alves, Armando Jardim, Ndao Momar, Eric Dumonteil, Daria Mochly-Rosen
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320716300100

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http://www.sciencedirect.com/science/article/pii/S2211320716300100

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