Substituted <i>N</i>-(Pyrazin-2-yl)benzenesulfonamides; Synthesis, Anti-Infective Evaluation, Cytotoxicity, and In Silico Studies

Substituted <i>N</i>-(Pyrazin-2-yl)benzenesulfonamides; Synthesis, Anti-Infective Evaluation, Cytotoxicity, and In Silico Studies

We prepared a series of substituted <i>N</i>-(pyrazin-2-yl)benzenesulfonamides as an attempt to investigate the effect of different linkers connecting pyrazine to benzene cores on antimicrobial activity when compared to our previous compounds of amide or retro-amide linker type. Only two...

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Bibliographic Details
Main Authors: Ghada Bouz, Martin Juhás, Lluis Pausas Otero, Cristina Paredes de la Red, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Vladimír Kubíček, Jiří Janoušek, Martin Doležal, Jan Zitko
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Molecules
Subjects:
anti-infectives
<i>mycobacterium tuberculosis</i>
pyrazinamide
sulfonamide
target fishing
Online Access:https://www.mdpi.com/1420-3049/25/1/138

Internet

https://www.mdpi.com/1420-3049/25/1/138

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