IRF7 Is Required for the Second Phase Interferon Induction during Influenza Virus Infection in Human Lung Epithelia

Influenza A virus (IAV) infection is a major cause of morbidity and mortality. Retinoic acid-inducible protein I (RIG-I) plays an important role in the recognition of IAV in most cell types, and leads to the activation of interferon (IFN). We investigated mechanisms of RIG-I and IFN induction by IAV...

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Bibliographic Details
Main Authors: Wenxin Wu, Wei Zhang, Lili Tian, Brent R. Brown, Matthew S. Walters, Jordan P. Metcalf
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/12/4/377